Section on Cellular Neurobiology

Y Loh, Section Head

We work to (1) investigate the mechanisms of biosynthesis and intracellular trafficking of peptide hormones and neuropeptides and their processing enzymes; (2) uncover mechanisms involved in the regulation of dense-core secretory granule biogenesis; and (3) determine the physiological roles of the prohormone processing enzyme carboxypeptidase E. Our work has led to the discovery of novel molecular mechanisms of protein trafficking to the regulated secretory pathway and identified players and mechanisms that control secretory granule biogenesis and transport in endocrine and neuroendocrine cells and neurons. Using cell lines, primary cell cultures, and mouse models, our studies have provided a better understanding of diseases related to defects in hormone and neuropeptide targeting, synaptic transmission, memory, learning, diabetes, and obesity.

Resources

• Employee Listing
• E-Mail the Lab: ypl@codon.nih.gov
• SCN Home Page